An improved synthesis of pyran-3, 5-dione: application to the synthesis of ABT-598, a potassium channel opener, via Hantzsch reaction

W Li, GS Wayne, JE Lallaman, SJ Chang…

Index: Journal of Organic Chemistry, , vol. 71, # 4 p. 1725 - 1727

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Citation Number: 14

Abstract

... Journal ... J. Org. Chem. ... The combined organic layer was washed with brine solution (2.7 kg). Analysis of the product solution by HPLC indicated 955 g (87.5%) of 3 present. The MTBE of 3 solution (6.43 kg, 948 g 3, 7.29 mol) was removed by distillation, and methanol was added. ...