Tetrahedron

A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives

JC González-Gómez, L Santana, E Uriarte

Index: Gonzalez-Gomez, Jose C.; Santana, Lourdes; Uriarte, Eugenio Tetrahedron, 2005 , vol. 61, # 20 p. 4805 - 4810

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Citation Number: 19

Abstract

A convenient preparation of the parent tetrahydrobenzodifuran was developed from resorcinol. The oxidation of one or both furan rings of this key intermediate was accomplished with DDQ and the resulting benzodifuran was subsequently reacted with 3, 6- dimethoxycarbonyl-1, 2, 4, 5-tetrazine to afford the expected pyridazino-psoralen derivative in good yield. This simple method allowed the efficient preparation of a pyridazino- ...