Tetrahedron letters

Synthesis of 4-substituted and 3, 4-disubstituted indazole derivatives by palladium-mediated cross-coupling reactions

S El Kazzouli, L Bouissane, M Khouili, G Guillaumet

Index: El Kazzouli, Said; Bouissane, Latifa; Khouili, Mostafa; Guillaumet, Gerald Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6163 - 6167

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Citation Number: 21

Abstract

The synthesis of 4-substituted indazole derivatives by palladium-mediated cross-coupling reactions was described. Suzuki, Heck, Sonogashira and Stille cross-coupling reactions were used to introduce aryl, vinyl and alkynyl substituents in 4-position of indazole derivatives. The selectivity of bis-Suzuki reactions of 3, 4-diiodo-and 3-bromo-4- iodoindazoles was investigated.

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