Tetrahedron: Asymmetry

Synthesis of enantiomerically pure β, β-diphenylalanine (Dip) and fluorenylglycine (Flg)

S Royo, AI Jiménez, C Cativiela

Index: Royo, Soledad; Jimenez, Ana I.; Cativiela, Carlos Tetrahedron Asymmetry, 2006 , vol. 17, # 16 p. 2393 - 2400

Full Text: HTML

Citation Number: 16

Abstract

A new strategy for the preparation of both enantiomers of two phenylalanine analogues, β, β- diphenylalanine and fluorenylglycine, has been developed. The combination of a high yielding racemic synthesis and a very efficient resolution procedure has provided significant amounts of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis. This methodology can be easily applied to the preparation of larger ...

Related Articles:

Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus.

[Eid, Clark N.; Halligan, Noreen G.; Nicas, Thalia I.; Mullen, Deborah L.; Butler, Thomas F.; Loncharich, Richard J.; Paschal, Jonathan W.; Schofield, Christopher J.; Westwood, Nicholas J.; Cheng, Leifeng Journal of Antibiotics, 1997 , vol. 50, # 3 p. 283 - 285]

Synthesis and biological activity of ketomethylene pseudopeptide analogs as thrombin inhibitors

[Cheng; Goodwin; Schully; Kakkar; Claeson Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3364 - 3369]

Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus.

[Eid, Clark N.; Halligan, Noreen G.; Nicas, Thalia I.; Mullen, Deborah L.; Butler, Thomas F.; Loncharich, Richard J.; Paschal, Jonathan W.; Schofield, Christopher J.; Westwood, Nicholas J.; Cheng, Leifeng Journal of Antibiotics, 1997 , vol. 50, # 3 p. 283 - 285]

Synthesis of α-amino acids via asymmetric phase transfer-catalyzed alkylation of achiral nickel (II) complexes of glycine-derived Schiff bases

[Belokon, Yuri N.; Bespalova, Natalia B.; Churkina, Tatiana D.; Cisarova, Ivana; Ezernitskaya, Marina G.; Harutyunyan, Syuzanna R.; Hrdina, Radim; Kagan, Henri B.; Kocovsky, Pavel; Kochetkov, Konstantin A.; Larionov, Oleg V.; Lyssenko, Konstantin A.; North, Michael; Polasek, Miroslav; Peregudov, Alexander S.; Prisyazhnyuk, Vladimir V.; Vyskocil, Stepan Journal of the American Chemical Society, 2003 , vol. 125, # 42 p. 12860 - 12871]

More Articles...