Synthesis of halogenated analogs of 5-(4-chlorophenyl)-2, 3-dihydro-5-hydroxy-5H-imidazo [2, 1-a]-isoindole or mazindol for exploration of the dopamine transporter

…, L Garreau, AM Dognon, JE Ombetta-Goka…

Index: Galinier; Garreau; Dognon; Ombetta-Goka; Frangin; Chalon; Besnard; Guilloteau European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 927 - 933

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Citation Number: 3

Abstract

Abstract In order to study the presynaptic dopamine transporter in the human brain by single photon emission tomography (SPET) or positron emission tomography (PET) we have developed new halogenated mazindol derivatives using a pathway involving a reaction between a dilithio derivative of 2-phenyl-2-imidazoline and appropriate methyl or ethyl halogenobenzoates. After HPLC purification and chemical characterization, the affinity for ...