Tetrahedron Letters

Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles

T Ponpandian, S Muthusubramanian

Index: Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252

Full Text: HTML

Citation Number: 25

Abstract

The efficient synthesis of 2-arylindoles and 6H-isoindolo [2, 1-a] indol-6-one through copper catalysed domino sp-sp2 decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo [1, 2-c] quinazolin-6 (5H)-one can be obtained with the elimination of trifluoromethyl anion.

Related Articles:

Cesium Carbonate??Promoted Hydroamidation of Alkynes: Enamides, Indoles and the Effect of Iron (III) Chloride

[Herrero, Maria Teresa; De Sarralde, Jokin Diaz; Sanmartin, Raul; Bravo, Laura; Dominguez, Esther Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3054 - 3064]

Microwave??Accelerated Pd??Catalyzed Desulfitative Direct C2??Arylation of Free (NH)??Indoles with Arylsulfinic Acids

[Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190]

Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride

[Yasuhara, Akito; Kanamori, Yuichi; Kaneko, Masashi; Numata, Atsushi; Kondo, Yoshinori; Sakamoto, Takao Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 4 p. 529 - 534]

Structure–activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus

[Ambrus, Joseph I.; Kelso, Michael J.; Bremner, John B.; Ball, Anthony R.; Casadei, Gabriele; Lewis, Kim Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4294 - 4297]

Microwave??Accelerated Pd??Catalyzed Desulfitative Direct C2??Arylation of Free (NH)??Indoles with Arylsulfinic Acids

[Miao, Tao; Li, Pinhua; Wang, Guan-Wu; Wang, Lei Chemistry - An Asian Journal, 2013 , vol. 8, # 12 p. 3185 - 3190]

More Articles...