The Journal of organic chemistry

Dehydroalanine-based inhibition of a peptide epimerase from spider venom

AS Murkin, ME Tanner

Index: Murkin, Andrew S; Tanner, Martin E The Journal of organic chemistry, 2002 , vol. 67, # 24 p. 8389 - 8394

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Citation Number: 28

Abstract

Ribosomally produced peptides that contain d-amino acids have been isolated from a number of vertebrate and invertebrate sources. In each case, the d-amino acids are introduced by a posttranslational modification of a parent peptide containing only amino acids of the l-configuration. The only known enzyme to catalyze such a reaction is the peptide epimerase (also known as peptide isomerase) from the venom of the funnel web ...