Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor

MI Abdullah, A Mahmood, M Madni, S Masood…

Index: Abdullah, Muhammad Imran; Mahmood, Asif; Madni, Murtaza; Masood, Sara; Kashif, Muhammad Bioorganic Chemistry, 2014 , vol. 54, p. 31 - 37

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Citation Number: 16

Abstract

Abstract A series of fourteen (A 1–A 14) new qunioline based chalcones were synthesized by condensing 2, 7-dichloro-8-methyl-3-formyl quinoline with acetophenone and acetylthiophenes, and subsequently characterized by IR, NMR and Mass spectroscopy. All the compounds were screened for antibacterial activities and found potentially active antibacterial agents. Bioassay, theoretical and dockings studies with DNA gyrase (the ...