Synlett

A new approach to 4-aryl-1, 3-butanediols by cobalt-catalyzed sequential radical cyclization-arylation reaction of silicon-tethered 6-iodo-1-hexene derivatives

H Someya, A Kondoh, A Sato, H Ohmiya, H Yorimitsu…

Index: Someya, Hidenori; Kondoh, Azusa; Sato, Akinori; Ohmiya, Hirohisa; Yorimitsu, Hideki; Oshima, Koichiro Synlett, 2006 , # 18 p. 3061 - 3064

Full Text: HTML

Citation Number: 5

Abstract

Abstract Treatment of 6-iodo-4-oxa-3-sila-1-hexene derivatives with arylmagnesium bromide in the presence of a catalytic amount of a cobalt-diamine complex in THF afforded the corresponding benzyl-substituted oxasilacyclopentanes in good yield. The products were converted to 4-aryl-1, 3-diols after Tamao-Fleming oxidation.