Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

C Liang, J Xia, D Lei, X Li, Q Yao, J Gao

Index: Liang, Chengyuan; Xia, Juan; Lei, Dong; Li, Xiang; Yao, Qizheng; Gao, Jing European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 742 - 750

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Citation Number: 33

Abstract

Abstract Eighteen symmetrical bis-Schiff base derivatives of isatin were synthesized by condensation of the natural or synthetic isatins with hydrazine and were evaluated for their in vitro and in vivo antitumor activities. More than half of the obtained compounds showed potent cytotoxicity according to the MTT assay on five different human cancer cell lines (ie HeLa, SGC-7901, HepG2, U251, and A549), with compound 3b 3, 3′-(hydrazine-1, 2- ...