Journal of Heterocyclic Chemistry

Problems related to the synthesis of 3??aziridinyl??6??chloropyridazine

WH Nyberg, CC Cheng

Index: Nyberg,W.H.; Cheng,C.C. Journal of Heterocyclic Chemistry, 1964 , vol. 1, p. 1 - 5

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Citation Number: 10

Abstract

Abstract The correct structure of the reported 3-aziridinyl-6-chloropyridazine was found to be 3-[β-(1-aziridinyl) ethylamino]-6-chloropyridazine, which was confirmed by nmr studies. The relative ease of nucleophilic displacement of a methylsulfonyl group versus a chloro group in equivalent positions on a pyridazine or a pyrimidine ring was compared. It was observed that the chloro rather than the methylsulfonyl group was preferentially replaced, as ...