The Synthesis of Certain Local Anesthetics of the Biphenyl Series

FH Case, E Koft Jr

Index: Case; Koft Journal of the American Chemical Society, 1941 , vol. 63, p. 508

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Citation Number: 6

Abstract

The synthesis of 4-nitro-4'-biphenylcarboxylic acid (intermediate in the preparation of V) was accomplished through the following series of reactions: $-toluidine--+ 4-methylbipheny14--+ 4-methyl-4'-nitrobiphenyl--+ 4-nitro-4'-biphenylcarboxylic acid. 5 The preparation of 5, 5'- dinitrodiphenic acid (used in the preparation of IV) was first effected by Pufah16 in the following manner: 4-nitro-2-aminobenzoic acid-+ 4-nitro-2-iodobenzoic acid--+ methyl ...