Preparative Synthesis via Continuous Flow of 4, 4, 5, 5-Tetramethyl-2-(3-trimethylsilyl-2-propynyl)-1, 3, 2-dioxaborolane: A General Propargylation Reagent

DR Fandrick, F Roschangar, C Kim…

Index: Organic Process Research and Development, , vol. 16, # 5 p. 1131 - 1140

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Citation Number: 15

Abstract

... reasonable yield of borolane 1 after an aqueous workup (Figure 1). Employing an azeotropic distillation to dry the wet organic layer, typical for production processes, with heptane ... Accordingly, only low to moderate yields are expected for the current process in production. ...

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