Synthesis and in vitro antitumour screening of 2-(β-d-xylofuranosyl) thiazole-4-carboxamide and two novel tiazofurin analogues with substituted tetrahydrofurodioxol …
…, M Svirčev, V Kojić, G Bogdanović, V Popsavin
Index: Popsavin, Mirjana; Spaic, Sasa; Svircev, Milos; Kojic, Vesna; Bogdanovic, Gordana; Popsavin, Velimir Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6700 - 6704
Full Text: HTML
Citation Number: 10
Abstract
2-(β-d-xylofuranosyl) thiazole-4-carboxamide (2) and two new tiazofurin analogues with 5- hydroxymethyl-2-methyl-tetrahydro-furo [2, 3-d][1, 3] dioxol-6-ol moiety as a sugar mimic (27 and 28) have been synthesized and evaluated for their in vitro antitumour activity against a panel of human tumour cell lines (K562, HL 60, Jurkat, Raji and HeLa). In contrast to previous literature reports, a metabolic MTT assay revealed remarkable cytotoxicity of 2 ...
Related Articles:
[Mao, David T.; Marquez, Victor E. Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2111 - 2114]
[Mao, David T.; Marquez, Victor E. Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2111 - 2114]
[Mao, David T.; Marquez, Victor E. Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2111 - 2114]
[Mao, David T.; Marquez, Victor E. Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2111 - 2114]
[Mao, David T.; Marquez, Victor E. Tetrahedron Letters, 1984 , vol. 25, # 20 p. 2111 - 2114]