Tetrahedron

A facile chemoenzymatic approach to natural cytotoxic ellipsoidone A and natural ellipsoidone B

S Gogoi, NP Argade

Index: Gogoi, Sanjib; Argade, Narshinha P. Tetrahedron, 2006 , vol. 62, # 11 p. 2715 - 2720

Full Text: HTML

Citation Number: 12

Abstract

Starting from citraconic anhydride () a facile four-step synthesis of deoxyellipsoidone has been reported with 37% overall yield. An elegant six-step access to naturally occurring cytotoxic ellipsoidone A () and ellipsoidone B () has been reported with good overall yields, via the conversion of itaconic anhydride () to the acetoxymethylmaleic anhydride (), regioselective sodium borohydride reduction of anhydride to acetoxymethylbutyrolactone, ...