Journal of Chemistry

Microwave-assisted synthesis of 3, 5-dibenzyl-4-amino-1, 2, 4-triazole and its diazo ligand, metal complexes along with anticancer activity

A Jha, YLN Murthy, G Durga, TT Sundari

Index: Jha, Anjali; Murthy; Durga; Sundari E-Journal of Chemistry, 2010 , vol. 7, # 4 p. 1571 - 1577

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Citation Number: 8

Abstract

Synthesis of 3, 5-dibenzyl-4-amino-1, 2, 4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2, 4-pentanedione. The dinucleating ligand was isolated and complexed with Ni (II), Cu (II) and Ru (III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.