Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

M Dolezal, P Cmedlova, L Palek, J Vinsova…

Index: Dolezal, Martin; Cmedlova, Pavlina; Palek, Lukas; Vinsova, Jarmila; Kunes, Jiri; Buchta, Vladimir; Jampilek, Josef; Kralova, Katarina European Journal of Medicinal Chemistry, 2008 , vol. 43, # 5 p. 1105 - 1113

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Citation Number: 57

Abstract

Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via–CONH–bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of 20 newly synthesized compounds are presented. Structure–activity relationships among the chemical structures, the antimycobacterial, antifungal, ...