Uridine 5'-diphosphate glucose analogs. Inhibitors of protein glycosylation that show antiviral activity

…, P Fernandez-Resa, MT Garcia-Lopez…

Index: Camarasa; Fernandez-Resa; Garcia-Lopez; De las Heras; Mendez-Castrillon; Alarcon; Carrasco Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 40 - 46

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Citation Number: 44

Abstract

Nucleoside diphosphate sugars are intermediates that donate glycosyl residues in the biosynthesis of polysaccharides, glycolipids, glycoproteins, and some components of the bacterial cell wall. Compounds that interfere with protein glycosylation show a variety of biological such as inhibition of the replication of enveloped animal For instance, 2-deoxy-~- glucose is a glycosylation inhibitor having antiviral activity, Pg which is transformed to ...