Organic letters

Reductive Alkylation of Indoles with Alkynes and Hydrosilanes under Indium Catalysis

T Tsuchimoto, M Kanbara

Index: Tsuchimoto, Teruhisa; Kanbara, Mitsutaka Organic Letters, 2011 , vol. 13, # 5 p. 912 - 915

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Citation Number: 24

Abstract

Under Indium catalysis, diverse alkylindoles were successfully prepared with a flexible combination of indoles and alkynes in the presence of hydrosilanes. In addition to the hydrosilane, carbon nucleophiles are also available. This new method generates alkylindoles in yields over 70% with a broad scope of functional group compatibility.