Synthesis of Substituted Pyridines by a Cycloaddition Route Using Nitrile Oxides and Homoallyl Alcohols

S Kanemasa, Y Asai, J Tanaka

Index: Kanemasa Asai; Tanaka Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380

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Citation Number: 12

Abstract

Cycloadditions of nitrile oxides with unprotected homoallyl alcohols, followed by Swern oxidations, lead to 5-(2-oxoalkyl)-2-isoxazolines. Subsequent Raney Ni reduction of the resulting heterocycles in ethanol in the presence of excess tetrafluoroboric acid affords substituted pyridine derivatives.

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