DNA-directed alkylating agents. 6. Synthesis and antitumor activity of DNA minor groove-targeted aniline mustard analogs of pibenzimol (Hoechst 33258)

GL Gravatt, BC Baguley, WR Wilson…

Index: Gravatt; Baguley; Wilson; Denny Journal of Medicinal Chemistry, 1994 , vol. 37, # 25 p. 4338 - 4345

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Citation Number: 176

Abstract

(0-20" CY2 days;(iii) EtOWglacial AcOW3 h. been widely studied for its sequence-specific interaction with DNA12-14 and has also undergone phase I clinical evaluation as an anticancer agent; 15 an analogue has recently been reported to have topoisomerase I activity. 16 We have been interested in using bisbenzimidazoles as DNA sequence- selective carriers of alkylating functionality and report here the synthesis and biological ...