Microwave promoted solvent-free one-pot synthesis of N, N '-disubstituted urea derivatives

VH Jadhav, SS Deshpande, HB Borate…

Index: Jadhav, Vinod H.; Deshpande, Shubhada S.; Borate, Hanumant B.; Wakharkar, Radhika D. Journal of Chemical Research, 2005 , # 3 p. 205 - 208

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Abstract

Symmetrical and unsymmetrical N,N'-disubstituted aryl/alkyl urea derivatives are well known for their biological activities including herbicidal properties,1-5 COX-2 inhibition6a and fat metabolism inhibition.7 Symmetrical disubstituted aromatic ureas are useful as agrochemicals and their intermediates8 and as stabilisers5,9 for smokeless gunpowder, propellants and solid rocket fuels. Diaryl urea derivatives have been reported10 recently for the treatment of disease states mediated by ...

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