One-step to get 5-azidomethyl-2′-deoxyuridine from 5-hydroxymethyl-2′-deoxyuridine and detection of it through click reaction

X Xu, S Yan, J Hu, P Guo, L Wei, X Weng, X Zhou

Index: Xu, Xiaowei; Yan, Shengyong; Hu, Jianlin; Guo, Pu; Wei, Lai; Weng, Xiaocheng; Zhou, Xiang Tetrahedron, 2013 , vol. 69, # 46 p. 9870 - 9874

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Abstract

Abstract Nowadays a few ways to synthesize 5-azidomethyl-2′-deoxyuridine from 5- hydroxymethyl-2′-deoxyuridine have been reported. But none of them was one-step. And many of them need to protect the hydroxyl group on the pentose ring. The detection of 5- hydroxymethyl-2′-deoxyuridine is also very important in many biological processes. However few fluorescence detection strategies have been tried to do this. Herein, we ...