An improved method for the synthesis of 3-amino-1 H-quinolin-2-one

C Juárez-Gordiano, A Hernández-Campos…

Index: Juarez-Gordiano, Cecilia; Hernandez-Campos, Alicia; Castillo, Rafael Synthetic Communications, 2002 , vol. 32, # 19 p. 2959 - 2963

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Citation Number: 4

Abstract

ABSTRACT An efficient method for the synthesis of 3-amino-1 H-quinolin-2-one is described. Condensation of o-nitrobenzaldehyde with hippuric acid gave 4-(2- nitrobenzylidene)-2-phenyloxazol-5-one. This compound was reduced to give 4-(2- aminobenzylidene)-2-phenyloxazol-5-one, which upon isomerization with light, cyclization and hydrolysis afforded the desired product.