Tetrahedron letters

Enzymatic kinetic resolution of 1, 1-dioxo-2, 3-dihydro-1H-1λ 6-thiophen-3-ol via temporary derivatisation

BS Morgan, SM Roberts, P Evans

Index: Morgan, Ben S.; Roberts, Stanley M.; Evans, Paul Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5273 - 5276

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Citation Number: 4

Abstract

Following the thio-conjugate addition of (±)-9, its enantiomers were extremely efficiently discriminated using Novozym 435®. The thio-differentiating unit may then be removed either under reductive conditions, using Raney nickel, or following an oxidation–elimination sequence. In this manner enantioenriched derivatives of 1, 1-dioxo-2, 3-dihydro-1H-1λ6- thiophen-3-ol 9 may be accessed.