The Journal of Organic Chemistry

. alpha.-Amino acids as chiral educts for asymmetric products. Aminoacylation of metallo alkyls and alkenyls

CG Knudsen, H Rapoport

Index: Knudsen, Christopher G.; Rapoport, Henry Journal of Organic Chemistry, 1983 , vol. 48, # 13 p. 2260 - 2266

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Citation Number: 63

Abstract

a-Amino acids have been developed as educts for the preparation of optically pure a-amino aliphatic ketones. The amino group of the L-amino acid was first blocked as a suitable acyl derivative, namely, acetyl, benzoyl, ethoxycarbonyl, or benzenesulfonyl. Then the lithium carboxylate was formed and treated with alkyl-and alkenyllithium or Grignard reagents. Thus butyl, allyl, and vinyl organometallics were added to the lithium carboxylates of~-aN- ...