The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters

…, S Choi, YJ Lee, J Lee, K Nahm, BS Jeong…

Index: Kim, Mi-Hyun; Choi, Sea-Hoon; Lee, Yeon-Ju; Lee, Jihye; Nahm, Keepyung; Jeong, Byeong-Seon; Park, Hyeung-Geun; Jew, Sang-Sup Chemical Communications, 2009 , # 7 p. 782 - 784

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Citation Number: 16

Abstract

The phase-transfer catalytic alkylation of N, N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S, S)-3, 4, 5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.