Concise Total Synthesis of Hydrazidomycin A, a Rare Hydrazide Metabolite of Streptomyces atratus

…, N Ueberschaar, C Hertweck

Index: Meyer, Florian; Ueberschaar, Nico; Hertweck, Christian European Journal of Organic Chemistry, 2013 , # 20 p. 4242 - 4244

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Citation Number: 2

Abstract

Abstract Hydrazidomycins A–C and elaiomycins B–C represent a family of unusual, naturally occurring enehydrazides produced by Streptomyces sp. A general synthetic approach to access these densely functionalized hydrazine derivatives is exemplified by the first total synthesis of hydrazidomycin A. The modular synthesis involves a ruthenium-catalyzed hydroamidation of an alkyne and a hydrazide-derived phthalimide to yield predominantly ...

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