Microsphere Formation in a Series of Derivatized. alpha.-Amino Acids: Properties, Molecular Modeling, and Oral Delivery of Salmon Calcitonin

A Leone-Bay, C McInnes, NF Wang…

Index: Leone-Bay, Andrea; McInnes, Campbell; Wang, NaiFang; DeMorin, Frenel; Achan, Doug; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 21 p. 4257 - 4262

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Citation Number: 54

Abstract

A series of benzoylated and phenylsulfonylated amino acids are novel, low molecular weight, self-assembling molecules. At low pH, these compounds form microspheres that dissolve readily under neutral conditions. In a given synthetic series, those molecules with low aqueous solubility formed microspheres more readily than did the molecules possessing high water solubility, suggesting that the hydrophobicity of these compounds ...