Synthesis of 2′, 3′, 4′-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation

YS Kim, SGL Keyser, JS Schneekloth

Index: Kim, Yeong Sang; Keyser, Samantha G.L.; Schneekloth Jr., John S. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 4 p. 1094 - 1097

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Abstract

Abstract Protein sumoylation is a dynamic posttranslational modification involved in diverse biological processes during cellular homeostasis and development. Recently sumoylation has been shown to play a critical role in cancer, although to date there are few small molecule probes available to inhibit enzymes involved in the SUMO conjugation process. As part of a program to identify and study inhibitors of sumoylation we recently reported the ...