Synthesis of a series of new racemic [2, 3-bis (acyloxy) propyl] phosphonocholines

P Mituła, C Wawrzeńczyk

Index: Mitula, Pawel; Wawrzenczyk, Czeslaw Arkivoc, 2012 , vol. 2012, # 4 p. 216 - 232

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Citation Number: 3

Abstract

Abstract An efficient synthesis of [2, 3-bis (acyloxy) propyl] phosphonocholines is described. The reaction pathway for the synthesis involves the Michaelis-Arbuzov reaction of allyl bromide with triethyl phosphite and epoxidation of the resulting diethyl (prop-2-en-1-yl) phosphonate (1) with m-CPBA to afford the phosphonated diol (3). The acylation of diol (3) with carboxylic acids gave a series of diacyloxypropylphosphonates (4). The introduction ...