Synthesis of Unsymmetrically Substituted Bipyridines by Palladium-Catalyzed Direct C− H Arylation of Pyridine N-Oxides

S Duric, CC Tzschucke

Index: Duric, Sasa; Tzschucke, C. Christoph Organic Letters, 2011 , vol. 13, # 9 p. 2310 - 2313

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Citation Number: 67

Abstract

Substituted bipyridines were efficiently prepared by direct coupling between pyridine N- oxides and halopyridines using a palladium catalyst. Pyridine N-oxides with electron- withdrawing substitutents gave the best yields. This method allows the convenient preparation of 2, 2′-, 2, 3′-, and 2, 4′-bipyridines which are useful as functionalized ligands for metal complexes or as building blocks for supramolecular architectures.