Synthesis and antitumor activity of novel benzophenone derivatives.

…, K Hirotani, SC Burford, K KAWAGOE, T MIWA…

Index: Kumazawa, Eiji; Hirotani, Kenji; Burford, S. Clifford; Kawagoe, Keiichi; Miwa, Tamotsu; Mitsui, Ikuo; Ejima, Akio Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 9 p. 1470 - 1474

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Citation Number: 22

Abstract

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, ...