Asymmetric Cyanation of α??Ketiminophosphonates Catalyzed by Cinchona Alkaloids: Enantioselective Synthesis of Tetrasubstituted α??Aminophosphonic Acid …

…, JM Ezpeleta, F Palacios

Index: Vicario, Javier; Ezpeleta, Jose Mari; Palacios, Francisco Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2641 - 2647

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Citation Number: 17

Abstract

Abstract An enantioselective synthesis of tetrasubstituted α-phosphono-α-amino nitriles through asymmetric cyanation of α-ketiminophosphonates catalyzed by Cinchona alkaloids is reported. α-Ketiminophosphonates are generated, in a very efficient synthetic protocol, by oxidation of trisubstituted α-aminophosphonates.

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