Synthesis of Dialkyl 1, 4??Dihydro??2, 6??dimethyl??4??(heteroaryl)??pyridine??3, 5??dicarboxylates as Calcium Channel Antagonists

RD Anana, EE Knaus

Index: Anana, Raymond D.; Knaus, Edward E. Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 2 p. 585 - 588

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Abstract

Abstract The Hantzsch condensation of the heteroarylcarboxaldehydes 3a-c with alkyl acetoacetates 4a-c and alkyl 3-aminocrotonates 5a-b afforded the respective dialkyl 1, 4- dihydro-2, 6-dimethyl-4-(heteroaryl)-pyridine-3, 5-dicarboxylates 6a-f possessing a C-4 4- quinolinyl, 8-quinolinyl or 1-oxido-4-pyridinyl substituent Calcium channel antagonist structure-activity relationships acquired indicate that i) the position of the quinolyl nitrogen ...