Synthesis, crystal structure, DNA-binding and cytotoxicity in vitro of novel cis-Pt (II) and trans-Pd (II) pyridine carboxamide complexes

CY Shi, EJ Gao, S Ma, ML Wang, QT Liu

Index: Shi, Chun-Yue; Gao, En-Jun; Ma, Shuang; Wang, Mei-Lin; Liu, Qi-Tao Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7250 - 7254

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Citation Number: 35

Abstract

In an attempt to establish fundamental structure–activity relationships (SAR) of Pt/Pd-based anti-tumour compounds, we have recently designed monodentate pyridyl amide ligand containing central amide units which possess external metal co-ordinating pyridyl group and internal amide functionality. It was prepared in one step from commercially available compounds in moderate to good yield. Surprisingly, treatment of K2 [MCl4][M= Pt (II), Pd (II ...