Synthesis and biological activities of chloroethylurea, methylurea, and nitrosourea analogs of N-deacetylmethylthiocolchicine

…, GT Shiau, WH Prusoff, RE Harmon

Index: Lin, Tai-Shun; Shiau, George T.; Prusoff, William H.; Harmon, Robert E. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1440 - 1442

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Citation Number: 9

Abstract

A series of urea and nitrosourea analogues of N-deacetylmethylthiocolchicine (1) has been synthesized, and their antineoplastic and antiviral activities were evaluated. The objective for combination of two active moieties, such as thiocolchicine and nitrosourea, into one molecule was the generation of compounds with potential improved biological and pharmacological properties. The EDm for 2, 3, 4, and 5 was 1.6, 1.2, 3.3, and 1.8 X lo4 M ...