Synthesis and structure–activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure

…, A Kakefuda, H Yamada, T Ogiyama, T Taguchi…

Index: Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Ogiyama, Takashi; Taguchi, Taku; Sakamoto, Shuichi Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 725 - 734

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Citation Number: 13

Abstract

In the context of heart failure and myocardial ischemia reperfusion, the activity of the sodium– calcium exchanger can lead to calcium overload, which in turn can lead to contractile dysfunction and arrhythmia. Therefore, NCX is an attractive target for treatment of heart failure and myocardial ischemia reperfusion. We have designed and synthesized a series of benzyloxyphenyl derivatives as potential NCX inhibitors, based on compound 4. These ...

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