Azo??Propofols: Photochromic Potentiators of GABAA Receptors

M Stein, SJ Middendorp, V Carta, E Pejo…

Index: Stein, Marco; Trauner, Dirk; Middendorp, Simon J.; Carta, Valentina; Sigel, Erwin; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A. Angewandte Chemie, International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504,5 Angewandte Chemie, 2012 , vol. 124, # 42 p. 10652 - 10656,5 Title/Abstract Full Text Show Details Stein, Marco; Middendorp, Simon J.; Carta, Valentina; Pejo, Ervin; Raines, Douglas E.; Forman, Stuart A.; Sigel, Erwin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 42 p. 10500 - 10504 Angew. Chem., 2012 , vol. 124, # 42 p. 10652 - 10656,5

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Citation Number: 66

Abstract

GABAA receptors are pentameric ligand-gated ion channels that are activated by the major inhibitory neurotransmitter in the mammalian brain, g-aminobutyric acid (GABA).[1] Binding of GABA results in the opening of a chloride ion selective pore, thus hyperpolarizing the postsynaptic neuron and decreasing the likelihood of action-potential firing. As such, GABAA receptors are a prominent target for anesthetic, hypnotic, and anticonvulsant drugs ( ...