Synthesis of Novel and Stable 5-Aminolevulinic Acid Derivatives for the Efficient Synthesis of 5-Aminolevulinic Acid Based Prodrugs

R Vallinayagam, H Bertschy, Y Berger, V Wenger…

Index: Vallinayagam, Ramakrishnan; Bertschy, Hugo; Berger, Yann; Wenger, Virginie; Neier, Reinhard Synthesis, 2007 , # 23 p. 3731 - 3735

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Citation Number: 8

Abstract

5-Aminolevulinic acid, an unusual amino acid, possesses high water solubility and corresponding low lipid solubility and thereby has limited ability to cross biological membranes. Various 5-aminolevulinic acid esters have been synthesized to obtain more lipophilic prodrugs. [4] 5-Aminolevulinic acid hydrochloride (ALA·HCl) is used as the starting material for the synthesis of the corresponding 5-aminolevulinic acid prodrugs in most published reports. 5-Aminolevulinic acid ...