Process development and scale-up of an Hsp90 inhibitor

S Duan, S Venkatraman, X Hong…

Index: Organic Process Research and Development, , vol. 16, # 11 p. 1787 - 1793

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Citation Number: 8

Abstract

... Compound 10 was found to be poorly soluble in most organic solvents, and hence a ... Thus, the process was modified to add hydrogen peroxide over an extended time to control ... The initially developed isolation procedure for 7 following an aqueous quench and extractive workup ...