Pd-catalyzed regiocontrolled Sonogashira and Suzuki cross-coupling reaction of 3, 6-dihalogenoimidazo [1, 2-a] pyridines: one-pot double-coupling approach

…, S Berteina-Raboin, A Mouaddib, G Guillaumet

Index: El Akkaoui, Ahmed; Bassoude, Ibtissam; Koubachi, Jamal; Berteina-Raboin, Sabine; Mouaddib, Abderrahim; Guillaumet, Gerald Tetrahedron, 2011 , vol. 67, # 37 p. 7128 - 7138

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Citation Number: 25

Abstract

New and efficient regioselective Sonogashira and Suzuki–Miyaura palladium-catalyzed coupling reactions of 3, 6-dihalogenoimidazo [1, 2-a] pyridines followed by another cross- coupling has been successfully developed. Various solvents, palladium species and bases were tested. Scope and limitations of this regiocontrolled palladium-catalyzed reaction were investigated. The synthesis of 3, 6-disubstituted imidazo [1, 2-a] pyridine derivatives using ...