Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis

…, Y Jeong, H Lee, SS Hong, S Hong

Index: Kim, Okseon; Jeong, Yujeong; Lee, Hyunseung; Hong, Sun-Sun; Hong, Sungwoo Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2455 - 2466

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Citation Number: 53

Abstract

Phosphatidylinositol 3-kinase α (PI3Kα) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the PI3K pathway is frequently up-regulated in human cancers, the inhibition of PI3Kα can be a promising approach to cancer therapy. In this study, we have designed and synthesized a new series of imidazo [1, 2-a] pyridine derivatives as PI3Kα inhibitors through the fragment ...