A synthesis of mycalamide B

PJ Kocienski, R Narquizian, P Raubo, C Smith…

Index: Kocienski, Philip J.; Narquizian, Robert; Raubo, Piotr; Smith, Christopher; Boyle, F. Thomas Synlett, 1998 , # 8 p. 869 - 872

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Citation Number: 21

Abstract

Abstract: Mycalamide B, a potent antitumour agent, was synthesised from cheap, readily available starting materials: ethyl lactate, ethyl isobutyrate, 4-chlorobutanal, and 4- chlorobutanoyl chloride. The trioxabicyclo [4.4. 0] decane ring system was created by reaction of a methoxymethyl ether with a silyloxyoxirane induced by phosphorus pentoxide.