Tetrahedron letters

L-Ascorbic acid in organic synthesis: A facile synthesis of 4-(butenolide-5-methylidenyl)-1, 4-dihydropyridines

SS Bisht, N Dwivedi, RP Tripathi

Index: Bisht, Surendra S.; Dwivedi, Namrata; Tripathi, Rama P. Tetrahedron Letters, 2007 , vol. 48, # 7 p. 1187 - 1189

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Citation Number: 16

Abstract

An efficient synthesis of 4-(butenolide-5-methylidenyl)-1, 4-dihydropyridines has been achieved via a three-component reaction of β-keto esters or ketones, ammonium acetate and vinylic aldehydes from ascorbic acid in the presence of tetrabutylammonium hydrogen sulfate in ethylene glycol.