Synthetic Communications

Microwave-assisted and iodine-catalyzed synthesis of dihydropyrimidin-2-thiones via biginelli reaction under solvent-free conditions

Q Liu, N Pan, J Xu, W Zhang, F Kong

Index: Liu, Qingjian; Pan, Ning; Xu, Jiehua; Zhang, Wenwen; Kong, Fanpeng Synthetic Communications, 2013 , vol. 43, # 1 p. 139 - 146

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Citation Number: 14

Abstract

View all references ] a one-pot condensation of aldehyde, acetoacetate, and urea under strongly acidic conditions, is one of the most useful multicomponent reactions (MCRs), gaining increasing importance in organic and medicinal chemistry because of its the capacity to generate multifunctionalized products including 3,4-dihydropyrimidin-2-ones, their thiones analogs, and other related heterocyclic compounds. Therefore, many improvements and modifications of the Biginelli reaction ...