Tetrahedron letters

A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin

LJ Wilson, SR Klopfenstein, M Li

Index: Wilson, Lawrence J.; Klopfenstein, Sean R.; Li, Min Tetrahedron Letters, 1999 , vol. 40, # 21 p. 3999 - 4002

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Citation Number: 40

Abstract

Solid phase synthesis of a series of substituted guanidines based on a novel acyl isothiocyanate resin is presented. This method provides both mono and disubstituted guanidines with a variety of sterically demanding and/or electron withdrawing substituents in good purities and yields.

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