Tetrahedron: Asymmetry

Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

M Calmès, F Escale, J Martinez

Index: Calmes, Monique; Escale, Francoise; Martinez, Jean Tetrahedron Asymmetry, 2002 , vol. 13, # 3 p. 293 - 296

Full Text: HTML

Citation Number: 11

Abstract

The synthesis of (±)-N-phthalyl α-phenyl-γ-aminobutyric acid and its asymmetric transformation via ketene formation have been investigated, allowing, after hydrolysis and amine protection, the preparation of the enantiomerically pure N-Boc-(R)-α-phenyl-γ- aminobutyric acid.

Related Articles:

An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

[Gil, Salvador; Parra, Margarita; Rodriguez, Pablo Molecules, 2008 , vol. 13, # 4 p. 716 - 728]

A simple synthesis of γ-aminoacids

[Gil, Salvador; Parra, Margarita; Rodriguez, Pablo Tetrahedron Letters, 2007 , vol. 48, # 19 p. 3451 - 3453]

More Articles...