Practical Asymmetric Synthesis of an Edivoxetine· HCl Intermediate via an Efficient Diazotization Process

ME Kopach, PC Heath, RB Scherer…

Index: Buckley, Benjamin R.; Patel, Anish P.; Wijayantha Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 1289 - 1292

Full Text: HTML

Citation Number: 2

Abstract

... Select a Journal or Book ... Although up to an 8% yield of the undesired R enantiomer could be rejected in the downstream crystallization of 1, it was ... After the n-heptane extraction, a solution of p-TsOH monohydrate (2 equiv) in deionized water (1 volume) was added to the ...

Related Articles:

A general method for deprotection of N-toluenesulfonyl aziridines using sodium naphthalenide

[Bergmeier, Stephen C.; Seth, Punit P. Tetrahedron Letters, 1999 , vol. 40, # 34 p. 6181 - 6184]

Observations on the modified Wenker synthesis of aziridines and the development of a biphasic system

[Journal of Organic Chemistry, , vol. 78, # 3 p. 1289 - 1292]

More Articles...