Tetrahedron letters

Microwave-assisted synthesis of the Schöllkopf chiral auxiliaries:(3S)-and (3R)-3, 6-dihydro-2, 5-diethoxy-3-isopropyl-pyrazine

…, M Tullberg, Å Pilotti, P Ioannidis, K Luthman, M Grøtli

Index: Carlsson, Anna-Carin; Jam, Fariba; Tullberg, Marcus; Pilotti, Ake; Ioannidis, Panos; Luthman, Kristina; Grotli, Morten Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5199 - 5201

Full Text: HTML

Citation Number: 24

Abstract

A practical and efficient methodology for the laboratory scale preparation of Schöllkopf's bis- lactim ether chiral auxiliaries (3S)-and (3R)-3, 6-dihydro-2, 5-diethoxy-3-isopropyl-pyrazine has been developed. The key step is the preparation of the 2, 5-diketopiperazine derivative by microwave-assisted heating in water. The protocol avoids reactions at low temperature and the use of high boiling solvents. Only inexpensive and readily available starting ...

Related Articles:

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors

[Li, Xiaoyan; Yin, Wenyuan; Sarma, P.V.V. Srirama; Zhou, Hao; Jun Ma; Cook, James M. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8569 - 8573]

Stereoselective ring contraction of 2, 5-diketopiperazines: An innovative approach to the synthesis of promising bioactive 5-membered scaffolds

[Coursindel, Thibault; Restouin, Audrey; Dewynter, Georges; Martinez, Jean; Collette, Yves; Parrot, Isabelle Bioorganic Chemistry, 2010 , vol. 38, # 5 p. 210 - 217]

A Strategy Towards the Stereoselective Synthesis of 5-Hydroxylysine

[Synlett, , # 7 p. 1139 - 1141]

A Strategy Towards the Stereoselective Synthesis of 5-Hydroxylysine

[Synlett, , # 7 p. 1139 - 1141]

A Strategy Towards the Stereoselective Synthesis of 5-Hydroxylysine

[Synlett, , # 7 p. 1139 - 1141]

More Articles...